Of course, at the extreme
Largest gun
the largest was the "Gustav Gun," built in Essen, Germany in 1941 by the firm of Friedrich Krupp, A.G. Upholding a tradition of naming heavy cannon after family members, the Gustav Gun was named after the invalid head of the Krupp family Gustav Krupp von Bohlen and Halbach. The strategic weapon of its day, the Gustav Gun was built at the direct order of Adolph Hitler for the express purpose of crushing Maginot Line forts protecting the French frontier. To accomplish this, Krupp designed a giant railway gun weighing 1344 tons with a bore diameter of 800mm (31.5") and served by a 500-man crew commanded by a major general.
Two types of projectiles were fired using a 300-lb. charge of smokeless powder: a 10,584 lb. High explosive (HE) shell and a 16,540-lb. concrete-piercing projectile. Craters from the HE shells measured 30-ft wide and 30-ft deep while the concrete piercing projectile proved capable of penetrating 264-ft of reinforced concrete before exploding! Maximum range was 29 miles with HE shells and 23 miles with concrete piercing projectiles. Muzzle velocity was approximately 2700 f.p.s. Three guns were ordered in 1939. Alfried Krupp personally hosted Hitler and Albert Speer (Minister of Armaments) at the Rugenwald Proving Ground during the formal acceptance trails of the Gustav Gun in the spring of 1941.