I like Buffalo coming out of the East. I doubt the Rangers can make that series go more than 5 games, if they get that far. I think the Sens and Devils will wear each other out and fall to a well-rested Sabres team.
The West is a whole other story. I think the Ducks will beat the Vancouver Luongo's, but that Wings/Sharks series is a tough one. I'll give the edge to Detroit based soley on experience.
For the Cup, I'm going with Detroit in 6.