The .22 LR is effective within 150 meters (490 ft) (after 150 meters the ballistics of the round are such that the large "drop" will be difficult to compensate). The relatively short effective range, low report, and light recoil has made it a favorite for use as a target practice cartridge. The accuracy of the cartridge is good, but not exceptional; various cartridges are capable of the same or better accuracy. Still, the effectiveness of this cartridge is often underestimated. The trajectory of the .22 LR "has a 2.7 inch rise at 50 yards and 10.8 inch drop at 150 yards when zeroed at 100 yards."[1] "Practically speaking, a .22 LR rifle needs to be zeroed at about 75 yards to avoid over-shooting small animals like squirrels at intermediate distances." [2]
The newest commercial rimfire, the .17 Mach 2, is based on the .22 LR case, but is slightly stretched in length (case length is similar to the CCI Stinger) and necked down. The light, aerodynamic .17 caliber (4.5 mm) bullet gives a much higher velocity than the .22 LR, for similar energy and a much flatter trajectory, but at the expense of increased cost and noise.
As a hunting cartridge, the .22 LR is mainly used to kill small vermin such as rats and squirrels. It is also highly effective on rabbits at distances closer than 150 yards and on ground hogs, marmots, and foxes closer than 80 yards. It has been successfully used on large creatures such as coyotes, but range should be limited to no farther than 65 yards, head and chest shots are mandatory with the most powerful .22 cartridge the hunter can use accurately. The hunter would best find what cartridge out of the various high velocity and hyper velocity shoots well for him by preliminary testing. For greater range or larger game, a more powerful cartridge should be used to ensure a clean kill. Examples include larger rimfire rounds such as the .22 WMR, .17 HMR, or any centerfire cartridge. Like any bullet, the .22 LR is nonetheless dangerous and capable of killing humans and large animals at close range.